Abstract
Mass-directed isolation of the CH2Cl2/MeOH extract from the bark of an Australian plant, Macropteranthes leichhardtii, resulted in the purification of a new phenylpropanoid glucoside, macropteranthol (1), together with four known analogues (2-5). The structure of compound 1 was elucidated by NMR and MS data analyses and quantum chemical calculations. Compounds 3 and 5 showed inhibitory activity against tyrosyl-DNA phosphodiesterase I with IC50 values of ∼1.0 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Australia
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Combretaceae / chemistry*
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology*
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Inhibitory Concentration 50
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phenylpropionates / chemistry
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Phenylpropionates / isolation & purification*
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Phenylpropionates / pharmacology*
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Phosphodiesterase Inhibitors / chemistry
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Phosphodiesterase Inhibitors / isolation & purification*
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Phosphodiesterase Inhibitors / pharmacology*
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Phosphoric Diester Hydrolases / drug effects*
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Structure-Activity Relationship
Substances
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Glucosides
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Phenylpropionates
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Phosphodiesterase Inhibitors
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macropteranthol
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Phosphoric Diester Hydrolases
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tyrosyl-DNA phosphodiesterase